Patient compliance for metabolic evaluation and medical treatment (CoMET) in calcium-oxalate stone patients: prospective study by EULIS eCORE study group

Purpose In this study, we aimed to identify the compliance rates of calcium-oxalate stone patients for metabolic evaluation, diet and medical treatment and also determine the factors that are associated with poor compliance rates. Methods This study was conducted by the EULIS eCORE working group prospectively. In the initial visit, demographic and stone-related characteristics were recorded. Patients were suggested metabolic evaluation, dietary advices and medical treatment. Follow-up visit was performed after 3 months and compliance rates were recorded. Logistic regression analysis was performed to determine factors associated with poor compliance to metabolic evaluation, diet and medical treatment. Results Data of 346 patients from nine centers were analyzed. Compliance rates were 71.7%, 65.3%, and 63.7% for metabolic evaluation, diet, and medical treatment, respectively. In multivariate analysis, level of education ( p = 0.003), history of emergency department visit ( p = 0.04), number of stone surgeries ( p = 0.03), patient care in dedicated stone clinic ( p = 0.03), and history of shock wave lithotripsy ( p = 0.005) were detected as independent predictors of compliance to metabolic analysis. Level of education ( p < 0.001) and history of emergency department visit ( p = 0.01) were detected as independent predictors of patient compliance to diet. Number of stone episodes ( p = 0.03), family history of stones ( p = 0.02), and polypharmacy ( p < 0.001) were detected as independent predictors of patient compliance to medical treatment. Conclusions Patient compliance to metabolic evaluation, diet, and medical therapy is important for successful management of urolithiasis. Dietary advices and medications should be personalized by taking in to account the factors associated with poor compliance.