Analysis of Immune-Related and Angiogenesis-Related Genes in Hepatocellular Carcinoma: Implications for Prognosis and Drug Sensitivity

Abstract In this study, we conducted a comprehensive analysis of immune-related and angiogenesis-related genes (IRAR DEGs) in hepatocellular carcinoma (HCC). We utilized data from the TCGA-LIHC project and performed expression difference and correlation analysis, clinical prognosis analysis, enrichment analysis, correlation analysis with immune cell infiltration, construction of advanced prognostic models, and evaluation of drug sensitivity. Our findings revealed 18 IRAR DEGs associated with both immune response and angiogenesis in HCC. We identified significant expression differences and correlations among these genes. Additionally, we demonstrated their clinical relevance in terms of tumor stage, survival prognosis, and immune cell infiltration. Furthermore, we performed functional enrichment analysis and identified enriched pathways and biological processes. Our study provides valuable insights into the molecular mechanisms and clinical implications of IRAR DEGs in HCC, which may contribute to the development of targeted therapies and precision medicine approaches for HCC patients.