Alzheimer Hastalığında Antosiyaninlerin Önemi

The Importance of Anthocyanins in Alzheimer’s Disease The main pathological markers in Alzheimer’s dementia are amyloid plaques and neurofibrillary tangles. In addition, inflammation, oxidative stress, apoptosis, mitochondrial damage, and impaired calcium homeostasis also play a role in the process. Currently, no definitive treatment for Alzheimer’s disease has yet been found. Considering the multifactorial pathogenesis of Alzheimer’s disease, single-targeted treatment approaches are insufficient. For an effective treatment, treatment approaches that target more than one factor contributing to the progression of the disease should be adopted. There are various findings showing that most of the harmful effects of the processes involved in neurodegeneration are ameliorated by anthocyanins, which are in the flavonoid group of polyphenols. Studies have reported that anthocyanins have effects on oxidative and nitrosative stress, excitotoxicity, glial inflammation, protein aggregation and induction of apoptotic signaling proteins. Because of these functionalities, anthocyanins have therapeutic potential both as a dietary intervention and as the basis for future drug discovery efforts, making them an interesting compound to consider in the context of developing treatments for neurodegeneration. In this article, it is aimed to examine the effects and underlying mechanisms of anthocyanins on Alzheimer’s disease. Keywords: Dementia, Alzheimer’s disease, Polyphenols, Anthocyanin