Proliferative Activity In Acquired Cholesteatoma And Correlation With Its Aggressiveness.

Purpose of the study Cholesteatoma is a cystic non-neoplastic destructive disease of the temporal bone with unclear pathogenesis and bone resorption mechanism. Both molecular and cellular events control its activity. In this study, we investigated the expression of the proliferative marker (Ki-67) in human cholesteatoma tissues versus external canal skin tissues as control and correlate them with its bone destructive activity.