Aspirin Administration can not Improve Erectile Dysfunction, whether with Higher Dosage or Longer Duration

Abstract Background Aspirin is the most widely used medicine since its synthesis, we aim to investigate the controversial relationship between aspirin and erectile function. Methods Thirty-six healthy young rats were grouped and administrated with small (10 mg/kg/d) and big (150 mg/kg/d) dose aspirin for 1 and 3 months, respectively; eighteen rats with bilateral cavernous nerve crush (BCNC) process were gavaged with small dose aspirin for 1 month. The 6-keto PGF 1a , PGE 2 , and TXB 2 in corpus cavernosum were detected to verify the bioactivity of aspirin. The mICP, mICP/MAP ratio, and concentrations of total NO, cAMP, as well as cGMP were selected to determine the erectile function. Results For the healthy young rats, aspirin significantly decreased the 6-keto PGF 1a and PGE 2 levels than control group, however, mICP, mICP/ MAP, total NO, cAMP, and cGMP levels was similar, whether with bigger dosage or longer duration. In BCNC groups, aspirin also significantly inhibited prostaglandin productions, however, it did not improve the impaired erectile function as well. Conclusion Long-term aspirin (even with higher dosage or longer duration) administration did not strength nor deteriorate erectile function for healthy young rats, while it did not improve the BCNC-induced erectile dysfunction as well.