Front Cover: Perillaldehyde Mitigates Ionizing Radiation‐Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway

Molecular Nutrition & Food Research(2023)

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摘要
Mol. Nutr. Food Res. 2023, 67, 202300232 DOI: 10.1002/mnfr.202300232 In article 2300232, Zhen-Xin Wang, Ming Li, and co-workers suggest that PAH activates Nrf2 signaling after ionizing radiation, and thus Nrf2 inhibits ferroptosis by promoting Slc7A11-mediated cystine input, GSH biosynthesis, and GPX4-mediated lipid peroxide detoxification. Therefore, PAH is a promising therapeutic strategy for radiation-induced intestinal injury.
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关键词
inhibiting ferroptosis,radiation‐induced
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