Role of Genetic Ancestry in Oropharyngeal Squamous-Cell Carcinoma: A Cross-Sectional Study in Brazil

Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC).The different ethnic backgrounds could be related to different susceptibility to Human Papillomavirus (HPV).The aim of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients.Methods: We conducted a cross-sectional study on patients with OPSCC admitted to the Barretos Cancer Hospital, Brazil from 2014 to 2019.Of these, DNA extraction was performed on 40 patients and genetic ancestry was assessed using a specific panel of 46 informative ancestry markers.Results: We observed a predominance of European ancestry (63%), followed by African (18%), Amerindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group.We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Amerindian (p = 0.836) ancestry.Conclusions: We found a predominance of European ancestry, both in the HPV-positive and HPV-negative groups.In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.