Innenrücktitelbild: Endogenous Enzyme‐Operated Spherical Nucleic Acids for Cell‐Selective Protein Capture and Localization Regulation (Angew. Chem. 18/2023)

Cell-selective regulation of protein translocation is achieved through the rational design of an endogenous enzyme-operated spherical nucleic acids platform. The system enables enzyme-activated capture of proteins of interest and thus regulation of their cytoplasmic-nuclear shuttling with tumor-cell specificity, as reported by Mengyuan Li and co-workers in their Research Article (e202214958).