YAP promotes AP-1 expression in tubular epithelial cells in the kidney

Yang Liu,Chunhua Xu,Jinhong Li,Yu Zhang,Xiaohua Wang,Yan Wang,Jinzhong Qin,Zhihua Zheng,Xia Yin

American Journal of Physiology-renal Physiology（2023）

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摘要

Yes-associated protein (YAP) activation leads to tubular injury, renal inflammation, and fibrosis, but the underlying mechanisms are not fully understood. We now provide genetic evidence that YAP promotes activator protein-1 expression and that Fosl1 is the primary target of YAP in renal tubular cells.

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关键词

tubular epithelial cells,tubular epithelial,epithelial cells,kidney

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