Prevalence of Brugada syndrome in a general population in south of Iran: Shiraz cohort heart study (SHS)

Abstract Brugada syndrome (BS) is a hereditary cardiac channelopathy associated with premature sudden cardiac death and arrhythmic events. However, there are limited data on prevalence of BS in Iran. This study aimed to evaluate the prevalence of BS and Brugada pattern on the electrocardiogram (ECG) in a general population located in south of Iran. BS and Brugada pattern were defined as the presence of type I and type II-III Brugada spontaneously or after a sodium channel blocker test, respectively. A total of 4000 participants (52.3% women) were enrolled in this study. Only 12 patients (0.3%) had Brugada ECG pattern and 4 ECGs were consistent with BS (0.1%). All 16 cases were followed up for 60 months. No mortality or cardiovascular events were observed during this period. This study showed a very low prevalence of BS and Brugada pattern in ECG in the general population of Iran.