Does menopause hormone therapy improve symptoms of depression?

It is well-established that menopause hormone therapy (MHT) is the most effective treatment option for the vasomotor and genitourinary symptoms associated with menopause. However, the effects of MHT on mood symptoms have been inconsistent. The objectives of this study was to assess whether symptoms of depression, as measured using the Centre for Epidemiological Studies Depression Short Depression Scale (CES-D-10), improved following a brief course of MHT among women seeking care for menopausal symptoms.