Simultaneous assessment of somatic mutations from multiple biofluids

Abstract Measurements of somatic mutations in biofluids (“liquid biopsies”) provide valuable clinical and biological insights. A mutational profile predominant in liquid biopsies is clonal hematopoiesis (CH), a condition resulting from mutations in genes which contribute to leukemia initiation. We hypothesized that mutational processes detected in liquid biopsies, such as CH, would differ across multiple biological specimens from the same patient and lead to novel technical and biological insights.