Ab0631 the relationship of lower urinary system symptoms with depression and anxiety in patients with sjögren’s syndrome

Background Sjögren’s syndrome (SS) is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible systemic multi-organ manifestations [1] . The prevalence and severity of lower urinary tract symptoms(LUTS) are higher in autoimmune diseases such as SS [2,3] . Likewise, the prevalence of anxiety and depression is increased in patients with Primary SS [4] . Objectives It was aimed to investigate the frequency of LUTS in patients with SS and to evaluate the coexistence of depression and anxiety in patients with and without LUTS. Methods Sixty-three patients, including sixty women diagnosed with Sjögren’s Syndrome at Sakarya University Faculty of Medicine, Internal Medicine Rheumatology Department, were included in the study after their informed consent was obtained. All patients fulfilled the criteria for the 2016 ACR/EULAR Classification for Primary Sjögren’s Syndrome. The International Prostate Symptom Score (IPSS) was used in the evaluation of LUTS, and the Beck Depression and Anxiety Scale were used for the assessment of depression and anxiety. Data were analyzed using the computer program SPSS 21. Relationships between categorical variables were evaluated with Chi-square analysis. The relationship between IPSS and Beck Depression/Beck Anxiety scale was assessed by spearman correlation analysis. p<0.05 was considered statistically significant. Results The mean age of the patients was 53.6±11.6 years. The median disease duration was four years (min-max: 0-40). 58 (92.1%) patients had at least one LUTS. Of the patients with LUTS, 32 (55.1%) were mild, 21 (36.2%) moderate, and 5 (8.7%) severe. Anxiety was found in 31 (49.2%) patients, and depression was found in 37 (58.7%) patients. The frequency of depression was significantly higher in patients with LUTS. Depression and anxiety were not observed in patients without LUTS. When the severity of LUTS was compared with the presence of anxiety and depression, a significant difference was found in both groups (p=0.033; p=0.032, respectively) (Table 1). There was a moderate positive correlation between the IPSS score and the Beck Depression and Beck Anxiety Scale (r:0.429 p:<0.001; r:0.481 p:0.001, respectively). Table 1. Association of LUTS severity and anxiety/depression. Mild n (%) Moderate n (%) Severe n (%) p value Depression Present 16 (50.0) 16 (76.2) 5 (100) 0,032 Absent 16 (50.0) 5 (23.8) 0 (0) Anxiety Present 13 (40.6) 16 (76.2) 2 (40.0) 0,033 Absent 19 (59.4) 5 (23.8) 3 (60.0) Conclusion In conclusion, questioning the presence of LUTS in patients with SS and referral for treatment may reduced the frequency of depression and anxiety. References [1]Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren’s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis Rheumatol . 2017;69(1):35-45. [2]Lee KL, Dong CS, Chen MY, et al. Multifactorial causes of irritating bladder symptoms in patients with Sjögren’s syndrome. Neurourol Urodyn. 2011;30(1):97-101. [3]Haarala M, Alanen A, Hietarinta M, Kiilholma P. Lower urinary tract symptoms in patients with Sjögren’s syndrome and systemic lupus erythematosus. Int Urogynecol J Pelvic Floor Dysfunct . 2000;11(2):84-86. [4]Cui Y, Xia L, Li L, Zhao Q, Chen S, Gu Z. Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study. BMC Psychiatry . 2018;18(1):131. Published 2018 May 16. Acknowledgements: NIL. Disclosure of Interests None Declared.