AB1518 INCIDENTALLY FOUND INTERSTITIAL LUNG DISEASE MAY NOT BE UNCOMMON IN FAMILIAL MEDITERRANEAN FEVER

Background Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by episodes of serositis and fever. Pleuritis is one of the common findings especially during attacks and thorax scans. However, data on other common lung findings such as interstitial lung disease (ILD) are limited in the literature. Objectives Here, we present the frequency of ILD and factors associated with ILD in our FMF cohort. Methods We included 242 patients who applied to the rheumatology outpatient clinic of a tertiary medical center within the last five years and were requested to undergo thoracic CT for any reason. The patients with a history of malignancy, active infection, active tuberculosis, or tuberculosis history, active or history of coronavirus 19 disease (COVID-19), nursing and pregnancy were excluded. An experienced radiologist blindly evaluated thoracic CT scans for ILD in accordance with relevant guidelines. We then evaluated the relationship between ILD findings and demographics and disease characteristics. Results Eleven (4.5%) of 242 patients had ILD. The most common ILD-related findings on thoracic CT were ground glass opacity (7/11 patients). None of the patients had honeycomb appearance. The most common reasons for requesting a thoracic CT were chest/chest pain, suspected COVID-19, and chronic cough. In addition, none of the demographic and disease-related characteristics were associated with ILD in our FMF patients (Table 1). Conclusion We have shown that incidentally diagnosed ILD is not uncommon in our FMF patients. In addition, FMF feature may not be associated with ILD in our patients. Reference [1]Lidar, M., et al., Thoracic and lung involvement in familial Mediterranean fever (FMF). Clin Chest Med, 2002. 23(2): p. 505-11. Acknowledgements: NIL. Disclosure of Interests None Declared.