THU256 Prevalence And Risk Factors Associated With Diabetes Mellitus Among Middle Aged Women In Southern Brazil: A Population Based Study

Abstract Disclosure: K. Oppermann: None. P.M. Spritzer: None. The prevalence of diabetes mellitus (DM) has been growing steeply. The early recognition of clinical characteristics related to DM may be determinant to reduce its prevalence in specific populations. The aim of this cross-sectional study, nested to the Passo Fundo cohort study, was to investigate the prevalence and the clinical factors associated with diabetes mellitus (DM) among middle-aged women. A total of 298 women were enrolled in which demographic, anthropometric characteristics, blood pressure (BP), use of hormone therapy (HT), physical activity (PA), smoking status, alcohol intake were obtained. Habitual PA was assessed by digital pedometer for 7 days, and participants were stratified into active and inactive (≥ 6,000 and < 6,000 steps/day, respectively). Mean age was 57.1±5.4 years, 78.7% women were postmenopausal, 8.3 % menopausal transition, 7.3% pre-menopause and 5.6% were classified as “hysterectomy” that is, those women who had previously undergone hysterectomy which menopause status could not be classified. The prevalence of DM was 17.1% (n= 51): pre-menopause 9.1%, menopausal transition 20.0%, post-menopause 18.4% and hysterectomized women, 5.9% (p=0.53). Women with DM were older (58.7 ±5.2 vs. 56.8 ± 5.4 years, p=0.022), worked fewer hours per week in the last month (p= 0.040), had lower age at menarche (12.6 ±1.8 vs. 13.2 ± 1.9 years, p=0.026), were more frequently inactive (83.7 vs. 64.7 %, p=0.010), had higher BMI (30.9 ± 6.3 vs. 28.4 ± 6.4 kg/m2, p=0.012), waist circumference (WC) (98.5 ± 13.2 vs. 90.3 ±13.3 cm) p<0.001), and higher visceral (218.5±85.2 vs. 164.9±71.6 p < 0.001) and total fat, (534.9 ±167.8 vs. 451.8±170.2 p=0.003) but not subcutaneous fat (315.5±117.3 vs. 286.9±118.7 p=0.140), and systolic blood pressure (SBP) (138.7 ± 17.3 vs. 130.2 ± 18.7 mmHg, p=0.003). The prevalence of current smoking was 19.5%, alcohol use was 32.5%, HT current use was 16.1% and it was not statistically different between women with and without DM. Women with DM presented higher prevalence of metabolic syndrome, 76.5% (n=39) vs. 34.8 % (n=86), p<0.001 as well as using statins more often (35.3% vs. 12.6%, p<0.001). A higher prevalence ratio of DM was associated with physical inactivity (PR 2.137; 95% CI 1.056-4.325; p<0.035). For each year of anticipated menarche, the risk of DM increases by 12% and for each mmHg there is an increase of 1.4% of DM diagnosis. Conclusion: The prevalence of DM among middle-aged women was 17.1%. Women with DM were older, have less working activity, earlier menarche, using statins more often and walk less. Also, they have higher BMI, waist circumference, visceral abdominal fat, and MS. Age, physical inactivity, early age at menarche, and systolic blood pressure were related independently to higher prevalence of DM in this unselected population of middle-aged women. Presentation: Thursday, June 15, 2023