Collateral sensitivity prevents antifungal drug resistance evolution in Candida auris
Research Square (Research Square)(2023)
摘要
Abstract The increased prevalence of antifungal drug resistance and emergence of multidrug-resistant species such as Candida auris represent a global public health threat. By mapping drug susceptibility responses of experimentally evolved C. auris across diverse antifungals, we found trends of cross-resistance (XR) and collateral sensitivity (CS) and show that CS can reduce resistance development through drug cycling and combination therapy, providing a promising direction for future research.
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关键词
antifungal drug resistance evolution,drug resistance
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