Front Cover Picture: From Peripheral Stereogenic Center to Axial Chirality: Synthesis of 3‐Arylthiophene Atropisomers (Adv. Synth. Catal. 4/2023)

The front cover picture illustrates the palladium-catalyzed the chirality transfer from peripheral stereogenic carbon center to axial chirality starting from 8H-indenothiophen-8-ols. The process is different from traditional point-to-axial chirality transfer aromatization reaction of a non-aromatic intermediate, in which the new created chiral axis is usually directly attach to a stereogenic centers. This reaction provides an easy way to access highly functionalized 3-arylthiophene atropisomers in high enantioselectivity. Details can be found in the Update by Junwei Xi, Zhenhua Gu and co-workers (L. Li, J. Xi, B. Hong, Z. Gu, Adv. Synth. Catal. 2023, 365, 594–599; DOI: 10.1002/adsc.202200957).