Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins

Camilla Valente Pires,Jenna Oberstaller,Chengqi Wang,Debora Casandra,Min Zhang,Jyotsna Chawla,Swamy Rakesh Adapa,Thomas D. Otto,Michael T. Ferdig,Julian C. Rayner,Rays H. Y. Jiang,John Adams

Microbiology spectrum（2023）

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摘要

Malaria control is seriously threatened by the emergence and spread of Plasmodium falciparum resistance to the leading antimalarial, artemisinin. The potent killing activity of artemisinin results from oxidative damage unleashed by free heme activation released by hemoglobin digestion.

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关键词

plasmodium falciparum,lipid metabolism,exported proteins

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