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    • Interrelations of Clinical, Neurophysiological and Neuroimmunological Parameters in Depressive Patients after COVID-19

    A. F. Iznak,E. V. Iznak,S. A. Zozulya,E. V. Damyanovich,I. V. Oleichik

    Psikhiatriya（2023）

    FSBSI “Mental Health Research Centre”

    Cited 1|Views6
    Abstract
    The aim of the study was to assess the impact of the coronavirus infection on clinical, neurophysiological and neuroimmunological parameters, as well as on their interrelations in young female depressive patients. Patients: a comparative analysis of quantitative clinical (according to the HDRS-17 scale), neurophysiological (EEG) and neuroimmunological (according to the “Neuro-immuno-test” technology) parameters was carried out in two groups of female depressive patients aged 16–25 years. The first group included 46 patients who recovered from a mild or asymptomatic coronavirus infection (“COVID” group). The second group included 40 patients who were studied and treated before the start of the pandemic (i.e., those who did not have COVID — the “pre-COVID” group) and corresponding to patients of the first group by gender, age, diagnoses, and syndrome structure of disorders. In all patients, prior to the start of the course of therapy, a multichannel EEG was recorded with the measurement of absolute spectral power and neuroimmunological parameters in blood plasma were determined. Methods: clinicalpsychopathological, psychometric, neurophysiological, neuroimmunological, statistical. Results: significantly greater scores of somatic disorders cluster of HDRS-17 scale, and increased amount of slow-wave EEG activity (of delta, theta1 and theta2 subbands) were revealed in the “COVID” group in comparison to patients of “pre-COVID” group. Mean values of neuroimmunological parameters were not differed statistically between two groups, but the values of neuroplasticity markers (levels of autoantibodies to the S100b protein and to the basic myelin protein) in the “pre-COVID” group correlated positively with the spectral power values of the main EEG rhythm (alpha2 and alpha3 sub-bands), and in “COVID” group — with the values of the spectral power of slow-wave EEG activity, reflecting a reduced brain functional state. Conclusion: the results obtained indicate that coronavirus infection, even in mild or asymptomatic forms, affects the clinical, neurophysiological and neuroimmunological parameters, as well as their interrelations in young female depressive patients.
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    【要点】：本研究探讨了新冠病毒感染对年轻女性抑郁症患者临床、神经生理和神经免疫参数及其相互关系的影响，发现即使轻症或无症状感染也会对上述参数产生影响。
    

    【方法】：采用临床心理病理学、心理测量学、神经生理学、神经免疫学及统计学方法，对两组年龄、性别、诊断和症状结构匹配的年轻女性抑郁症患者进行比较分析。
    

    【实验】：对46名经历轻症或无症状新冠病毒感染（COVID组）的抑郁症患者和40名疫情前接受治疗（pre-COVID组）的患者进行了HDRS-17量表评估、多通道脑电图记录和血液神经免疫参数检测。结果显示COVID组在HDRS-17量表中的身体症状集群得分更高，慢波脑电活动（delta、theta1和theta2子带）增加；两组神经免疫参数均值无统计学差异，但pre-COVID组的神经可塑性标志物水平与主要脑电节律的谱功率值呈正相关，而COVID组则与慢波脑电活动谱功率值呈正相关，反映了脑功能状态的降低。
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