A Biomimetic Peptide Functions as Specific Extracellular Matrix for Quiescence of Stem Cells against Intervertebral Disc Degeneration (Small 44/2023)

Yuan Li,Kuo Zhang,Xuezheng Ai, Qingning Zhang, Lu Jiang,Long Jiang,Huange Xu,Chencheng Feng, Yaqing Zhang, Guoke Tang,Fanli Chong,Lei Wang,Bo Huang

Small（2023）

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摘要

Intervertebral Disc Degeneration A biomimetic peptide (OAFF) binds to C-X-C motif chemokine receptor 1 (CXCR1) and forms fibrous networks on nucleus pulposus stem cells (NPSCs) for mimicking extracellular matrix formation, which induces NPSCs quiescence and ultimately overcomes obstacle in intradiscal injection therapy. More details can be found in article number 2300578 by Lei Wang, Bo Huang, and co-workers.

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关键词

intervertebral disc degeneration,biomimetic peptide functions,extracellular matrix,specific extracellular matrix,stem cells

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