Two New Antifungal Aromatic Sesquiterpenes from the Leaves of Cigar Tobacco

Two new aromatic sesquiterpenes, (1-isopropyl-6-methoxy-3-methylnaphthalen-7-yl)methanol (1) and 1-isopropyl-6-methoxy-3,7-dimethylnaphthalene (2), as well as five known ones (3–7) were isolated from the leaves of cigar tobacco. Their structures were determined mainly using spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly, the anti-fungi activity test revealed that compounds 1 and 2 showed potential anti-Golovinomyces cichoracearum (the main pathogen of tobacco powdery mildew disease) activity with inhibition rates of 55.4