Insulin resistance is associated with increased DNA-damage, senescence associated secretory phenotype and decreased kidney function in pre-diabetes and type 2 diabetes.

Dimitrios Tsilingiris,Ζoltan Κender,Alba Sulaj,Elisabeth Kliemank,Ekaterina von Rauchhaupt,Lukas Schimpfle,Lukas Seebauer,Thomas Fleming,Stephan Herzig,Julia Szendrödi,Stefan Kopf

Diabetologie Und Stoffwechsel（2023）

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摘要

Question Increased DNA-damage and senescence are associated with progression of diabetic complications. The underlying mechanisms are yet unclear. Aim of this study is to investigate the relation of DNA-damage and senescence-associated-secretory-phenotype (SASP) with insulin resistance and beta-cell function in type 2 diabetes and pre-diabetes.

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insulin resistance,dna-damage dna-damage,pre-diabetes

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