Development of Release-Modulated Oxaceprol Topical Niosomal Gel: Assessment of Formulation Parameters and Performance Aspects

The ultimate aim of the present investigation was to develop release-modulated oxaceprol topical niosomal gel and assessment of its in vitro and ex vivo performance characteristics. Oxaceprol belongs to the class of drugs treating burn infections by regeneration of tissue in the burned area by stimulating the uptake of 3H- glucosamine and 3H-proline and its incorporation in the macromolecular structure of the matrix of cartilage as the blood circulation is impaired in the burned area, oral medication inefficient to target the affected area. To achieve both localized drug concentration and sustained retention at the point of application, we employed Carbopol as a polymer capable of regulating drug release. Entrapment efficiency (percent EE), particle size, zeta potential, Fourier transform infrared analysis, etc., were some of the preliminary characterizations of the improved system. Additionally, rheological behaviour, drug release in vitro, and ex vivo permeability were investigated as performance features. Moreover, the influence of several formulation factors on drug entrapment in niosomal vesicles, such as surfactant type, surfactant to cholesterol ratio, and chloroform to methanol ratio, was assessed. The optimized batch showed sustained, regulated drug release for up to 12 h. Potentially useful in the near future as an alternative to current therapeutic methods, this niosomal gel has been produced.