HPV 67 in Cervical Metastasis of a Squamos Cell Carcionama in a Patien with "cancer of Unknown Primary"

Introduction Cervical lymph node metastases of squamos cell carcinomas are frequent cause of neck swelling. Immunohistochemical detection of p16 and detection of HPV DNA from the tumor cells suggest a primary cancer in the oropharynx. In 95% of all cases, it shows HPV type 16. The examination protocols allow the detection of other high-risk HPV types, such as types 31 and 33. Although HPV type 67 is classified as a high-risk strain by the WHO, it has never been described as the trigger of HNSCC in the literature.