Risk Factors for the Development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, Following Drug Administration: a Systematic Review and Meta-Analysis.

The aim of this systematic review was to determine risk factors for the development of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN), following drug administration. The study protocol was registered on PROSPERO. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. On 17th October 2022, a search, advised by a librarian, was conducted in Medline and EMBASE. Five studies were pooled. We report that HIV and male gender may be risk factors for SJS/TEN however this review was limited by a low number, and quality, of included studies. We conclude a well-designed, large population-based case-control study with an appropriate control group is required to assess risk factors for development of drug-induced SJS/TEN.