Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microglia

Yan Mi,Jikai Xu, Runbin Shi,Qingqi Meng,Libin Xu,Ye-Shu Liu,Tingting Guo,Di Zhou,Jingyu Liu,Wei Li, Ning Li,Yue Hou

Food & Function（2023）

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摘要

Okanin attenuated cognitive impairment in BCCAO mice. Okanin inhibited microglial activation, decreased NLRP3 inflammasome activation and increased miR-7 expression in vivo and in vitro, and inhibited microglia-induced neuronal injury.

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关键词

microglia,cognitive impairment,nutt

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