Quantitative differentiation of non-invasive bladder urothelial carcinoma and inverted papilloma based on CT urography

Pengfei Jin, Yang Long, Yitao Liu,Jie‐Hui Huang, Xuming Wang

Research Square (Research Square)(2023)

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摘要
Abstract Purpose To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB). Material and methods Retrospective analysis of clinical and imaging data of 103 patients who underwent CTU prior to transurethral resection of the bladder tumor or radical cystectomy from January 2019 to December 2022. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram. ROC curve analysis was used to calculate and compare the predictive efficacy of independent risk factors and nomogram. Results Junction smoothness, maximum longitudinal diameter, tumor-wall interface and arterial reinforcement rate were independent risk factors for distinguishing BUC from IPB. The AUC of the combined model was 0.934 (sensitivity = 0.808, specificity = 0.920, accuracy = 0.835), and its diagnostic efficiency was higher than that of junction smoothness (AUC = 0.667, sensitivity = 0.654, specificity = 0.680, accuracy = 0.660), maximum longitudinal diameter (AUC = 0.757, sensitivity = 0.833, specificity = 0.604, accuracy = 0.786), tumor-wall interface (AUC = 0.888, sensitivity = 0.755, specificity = 0.808, accuracy = 0.816) and Arterial reinforcement rate (AUC = 0.786, sensitivity = 0.936, specificity = 0.640, accuracy = 0.864). Conclusion Above qualitative and quantitative indicators based on CTU and the combination of them may be helpful to the differential diagnosis of BUC and IPB, thus better assisting in clinical decision-making.
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关键词
ct urography,urothelial carcinoma,papilloma,quantitative differentiation,non-invasive
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