Omix: A Multi-Omics Integration Pipeline

Abstract Summary The Omix pipeline offers an integration and analysis framework for multiomics intended to preprocess, analyse, and visualise multimodal data flexibly to address various research questions. From biomarker discovery and patient stratification to the investigation of complex biological processes, Omix empowers researchers to derive valuable insights from omics data. Using Alzheimer’s Disease (AD) bulk proteomics and transcriptomics datasets generated from two distinct regions derived from post-mortem brains, we demonstrate the utility of Omix in generating an integrated pseudo-temporal multi-omics profile of AD. Availability and Implementation Omix is implemented as a software package in R. The code for the Omix package is available at https://github.com/eleonoreschneeg/Omix . Reference documentation and online tutorials are available at https://eleonore-schneeg.github.io/Omix . All code is open-source and available under the GNU General Public License v3.0 (GPL-3). Contact eleonore.schneegans17@imperial.ac.uk , johanna.jackson@imperial.ac.uk