FRI399 Prevalence Of Polycystic Ovary Syndrome In Women With Type 1 Diabetes In Pregnancy

Disclosure: S. Dolatabadi: None. J.M. Yamamoto: None. J.L. Benham: None. Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that is a risk factor for cardiometabolic disease such as impaired glucose tolerance, obesity, and hypertension. The prevalence of PCOS in the general population is estimated at 5-15% depending on the diagnostic criteria that is used. Although PCOS is commonly associated with type 2 diabetes (T2D), its association with type 1 diabetes (T1D) is less commonly investigated. The reported prevalence of PCOS in women with T1D is 24%. Furthermore, previous studies have found that women with either PCOS or T1D are at risk of preeclampsia, premature delivery, and neonatal complications such as congenital malformations and neonatal death. Unfortunately, there is a paucity of information regarding prevalence of PCOS in women with T1D in pregnancy as well as maternal and neonatal outcomes in this population. The objectives for this study were to 1) determine the prevalence of PCOS in pregnancies affected by T1D and 2) determine whether maternal and neonatal outcomes differed between women with T1D in pregnancy with or without a concomitant diagnosis of PCOS. A retrospective cohort study was performed of women affected by T1D in pregnancy that attended specialized Diabetes in Pregnancy clinics in Calgary, Alberta, Canada between 2008-2020. An individual was classified as having PCOS if there was a self-reported diagnosis of PCOS or if a patient met at least 2 of the 3 Rotterdam criteria based upon chart review. Logistic regression was planned to examine associations between maternal and neonatal outcomes. From 401 patients with T1D seen at Diabetes in Pregnancy Clinics, 14 (3.5%) patients had a self-reported diagnosis of PCOS. Given the low prevalence of PCOS in our patient population, the planned comparison of maternal and neonatal outcomes in patients with and without PCOS could not be completed. The prevalence of PCOS in women affected by T1D in pregnancy in this cohort was significantly lower than the reported prevalence of PCOS among women with T1D as well as the general population. Given that PCOS is associated with infertility and only women experiencing pregnancy were included in this study, exclusion of patients experiencing infertility could have affected the calculated prevalence. Overall, these results indicate that there is a lack of screening for PCOS in women affected by T1D during pregnancy. Given that both T1D and PCOS are associated with adverse maternal and neonatal outcomes, more education regarding this topic should be provided to healthcare professionals to ensure appropriate periconceptional and antepartum care of women with PCOS and pre-existing diabetes. Presentation: Friday, June 16, 2023