Blocked-flow vs. free-flow cyanoacrylate glue embolization: Histological differences in an in vivo rabbit renal artery model

•Blocked-flow glue injection in renal rabbit arteries is associated with more acute vessel-wall damage, including intimal arteritis, intimal necrosis, and peri‑arterial edema.•Blocked-flow glue injection consistently enables greater distal glue penetration throughout the renal vascular tree, irrespective of the concentration used.•Further investigations are needed to determine if intra-arterial blocked-flow interventions are more associated with local symptoms such as pain and local inflammation.