Effect of a short-term glutamine supplementation in inflammation and oxidative stress post-resistance exercise in HIV women: a double-blind, randomized, crossover study

Abstract We evaluate the effect of a short-term supplementation with glutamine dipeptide (GluD) on the inflammatory and oxidative stress response to an acute session of resistance exercise in women living with HIV and using antiretroviral therapy (ART). Tenwomen diagnosed with HIV under ART were allocated in a randomized, double-blind, cross-over manner to receive 20 g/day of GluD or maltodextrin (placebo) supplementation for seven days with seven-days wash-out period. The participants performed an acute session of resistance training composed by seven exercises. Blood samples were taken before (pre), 1 hour and 2 hours after the exercise session for oxidative stress and inflammation markers determinations. Generalized estimating equations model, followed by the post-hoc Bonferroni test were used for statistical analysis. The resistance exercise session increased the concentrations of TNF-α, but the supplementation with GluD prevents this increase. Also, resistance exercise did not change plasma levels of IL-6.Regarding IL-10, there was a small reduction in both groups. For the oxidative stress markers, both conditions showed no change. A short period of GluD supplementation partially reduces the acute inflammatory response, caused by a session of resistance exercise, without altering the response of oxidative stress markers, in women living with HIV and using ART.