Combined influence of ACE and ACTN3 polymorphisms on vertical jump performance following resistance training in professional footballers

This study aimed to investigate whether a genetic-based algorithm derived from ACE (rs1799752) and ACTN3 (rs1815739) polymorphisms could be utilized to predict the magnitude of improvements in vertical jump performance following high-intensity resistance training. Twenty male professional footballers (age 18.7 ± 0.6 year; height 169.8 ± 2.7 cm, body mass 62.3 ± 6.0 kg) were recruited and allocated into “low” and “high” weighted total genotype score (TGS) groups based on the number of power/strength-associated ACE and ACTN3 polymorphisms. Explosive power of the lower limb was assessed by vertical jump test before and after an eight-week high-intensity resistance training. The magnitude of improvement was found to be significantly different between the high and low TGS groups (p = 0.042; d = 0.98) with greater improvement being observed in the high TGS group (15.4