A conformationally-locked p-hydroxybenzylidene imidazolinone derivative for detecting Aβ42 aggregation

Anyang Sun,Han Sun,Gulziba Anwar,Xiuhong Lu,Jinwu Yan

Bioorganic & Medicinal Chemistry Letters（2024）

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摘要

•A novel red fluorescence probe BDI is capable of preferentially detecting Aβ42 aggregation.•BDI binds to Aβ42 oligomers with specific fluorescent enhancement (47-fold).•BDI exhibits a good affinity (85.97 nM) toward Aβ42 oligomers with a large stokes shift.•In vitro experiment, BDI can stain Aβ42 oligomers in AD transgenic mouse brain sections.

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关键词

Alzheimer’s disease,Beta-amyloid,Fluorescent probe,Aβ42 aggregation

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