Contribution of water-soluble extracts to the oxidative and inflammatory effects of atmospheric aerosols: A critical review

Exposure to atmospheric particulate matter (PM) has been associated with heightened risks of lung cancer, cardiovascular and respiratory diseases. PM exposure also affects the immune system, leading to an increased susceptibility to infections, exacerbating pre-existent inflammatory and allergic lung diseases. Atmospheric PM can primarily impact human health through the generation of reactive oxygen species (ROS) that subsequently induce or exacerbate inflammation. These cytotoxic effects have been related with PM concentration, and its chemical constituents, including metals, solvent extractable organics (e.g., polycyclic aromatic hydrocarbons), and water-soluble ions. Although not receiving much attention, the fine aerosol water-soluble organic matter (WSOM) can account for a substantial portion of the overall fine PM mass and has been shown to present strong oxidative and immunomodulatory effects. Thus, the objective of this review is to provide a comprehensive analysis of the role of the water-soluble fraction of PM, with a specific focus on the contribution of the WSOM component to the cytotoxic properties of atmospheric PM. The chemical properties of the water-soluble PM fraction are briefly discussed, while emphasis is put on how PM size, composition, and temporal variations (e.g., seasonality) can impact the pro-oxidative activity, the modulation of inflammatory response, and the cytotoxicity of the water-soluble PM extracts.