The Prognostic Value of a Glycolysis -Related lncRNA Signature in Non-Small Cell Lung Cancer

Abstract Backgroud : Long non-coding RNA(lncRNA) is a new modulatory factor for glycolysis, which affect the development and progression of varities of cancers. However, poor attention has been drawn to the role of glycolysis-related lncRNAs in Non-small cell lung cancer(NSCLC) . Methods : The RNA sequencing(RNA-seq) data of NSCLC patients was downloaded from The Cancer Genome Atlas(TCGA) database. Glycolysis-related genes were identified using Gene Set Enrichment Analysis(GSEA). Cox regression analysis was used to construct the glycolysis-related signature. GSEA analysis was used for function assessment. Results : Firstly, a signature consisting of 8 glycolysis-related lncRNAs(AC090559.1, AC099850.3,AL365181.3, AL049555.1, AC024075.3, LINC01843, ATP13A4-AS1 and LINC01133)were estimated. Moreover, on the basis of this signature, we found that overall survival(OS) in high-risk group was markedly lower than that in low-risk group, and the prognostic prediction accuracy was further verified by Multi-parameter ROC curve analysis. Lastly, the 8 glycolysis-related lncRNAs were found to be closely associated with many cancer-related pathways. Conclusion : The 8 glycolysis-related lncRNAs could be promising prognostic and potential therapeutic targets for NSCLC.