Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and interventions in metabolism are considered fundamental approaches for cancer control. Within the vast metabolic networks of tumors, there exist numerous potential therapeutic targets, intricately interconnected with each other and with signaling networks related to immunity, metastasis, drug resistance, and more. Based on the characteristics of the tumor microenvironment, constructing drug delivery systems for multi-level modulation of the tumor microenvironment is proven as an effective strategy for achieving multidimensional control of cancer. Consequently, this article summarizes several features of tumor metabolism to provide insights into recent advancements in intelligent drug delivery systems for achieving multi-level regulation of the metabolic microenvironment in cancer, with the aim of offering a novel paradigm for cancer treatment. Latest advancements in intelligent drug delivery systems (DDS) exhibit distinctive advantages, including precise sensing, programmability, feedback control, and intrinsic activity. These attributes render them conducive to facilitating multi-dimensional therapeutic approaches grounded in metabolic regulation.image