Operationalizing Quality Assurance for Clinical Illumina Somatic Next-Generation Sequencing Pipelines.
The Journal of Molecular Diagnostics(2024)
摘要
Quality assurance (QA) is essential for precision oncology workflows, in particular in the clinical setting. However, because of numerous variations in laboratory and bioinformatics pipelines, QA practices remain non -standardized, are often ad hoc, and are lacking longitudinal tracking. A selected review of existing software was performed for quality control of Illumina next -generation sequencing data, focusing specifically on generalizable tools that can be integrated into any bioinformatics workflow to easily develop a QA workflow with longitudinal tracking. Although all implementations need to be integrated, validated, and iterated upon to suit individual operations, providing a base suite of options will enable better validation and use of QA in clinical somatic mutation testing for workflows using Illumina next -generation sequencing and beyond. (J Mol Diagn 2024, 26: 96e105; https://doi.org/ 10.1016/j.jmoldx.2023.11.006)
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要