The Enhanced Photocatalytic Sterilization of a Metal-Organic-Framework-Based S-Scheme Heterostructure of Ag₂S@PB for Rapid Healing of Bacteria-Infected Open Wounds

Developing new photocatalytic materials is one of the most promising strategies to address bacterial infection during wound healing without bacterial drug resistance, but their poor photocatalytic activity ultimately limits their therapeutic efficacy. In this work, a metal-organic framework-based S-scheme heterostructure (Ag2S@PB) is prepared to rapidly treat open wounds caused by bacterial infection, which effectively establishes and retains spatially isolated redox centers through an S-scheme charge-transfer pathway. Additionally, the formation of an interface electric field and covalent Fe-S bridge bonding in the heterogeneous interface endows the heterojunction with a much stronger charge separation and transfer capability than bare Ag2S, which significantly enhances the photocatalytic performance and stability, consequently generating more radical oxygen species. Meanwhile, the introduction of Prussian blue greatly improves the photothermal effect of the Ag2S@PB under 808 nm near-infrared light. Therefore, under illumination for 20 min, the Ag2S@PB shows a desirable antibacterial efficiency of 99.92% against Staphylococcus aureus and 99.86% against Escherichia coli. The in vivo wound repair experiment shows that the Ag2S@PB has good tissue repair effects and can expedite wound healing. This work will provide insights for designing highly efficient photoresponsive materials to treat bacterial wound infections.