Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1^8,12.0^{17,21< /SUP>]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate}

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1(8,12).0(17,21)]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macrocyclic quinoxaline compound was achieved using H-1 NMR, C-13 NMR, and HRMS spectral analysis. This new macrocyclic derivative demonstrated submicromolar potency on both Pim-1 and Pim-2 isoforms, with an interesting selectivity profile against a selected panel of human kinases.