Whole genome CRISPR screening identifies molecular mechanisms of PD-L1 expression in Adult T-cell leukemia/lymphoma

Masahiro Chiba,Joji Shimono,Keito Suto,Takashi Ishio,Tomoyuki Endo,Hideki Goto,Hiroo Hasegawa,Maeda Michiyuki,Takanori Teshima,Yibin Yang,Masao Nakagawa

Blood（2023）

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摘要

•Whole-genome CRISPR screening identified STAT3 or neddylation genes as positive or negative regulators in PD-L1 expression in ATLL cells•The pevonedistat improves the cytotoxic effects of the anti-PD-L1 antibody Avelumab and CAR-T cells targeting PD-L1 in ATLL cells

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