Surface enhanced Raman scattering based on ZnO/Cu@Ag heterojunction for detecting -aminobutyric acid molecules
Sensors and Actuators B: Chemical(2024)
摘要
Detecting gamma-aminobutyric acid (GABA) in the mammalian body is vital for diagnosing neurological disorders. Here, we introduced a novel SERS sensor based on metal-semiconductor heterojunction ZnO/Cu@Ag substrate for highly sensitive detecting GABA molecules. The ZnO/Cu@Ag substrate fully leverages the electromagnetic field enhancement effect and the chemical enhancement effect of metal-semiconductors heterojunction, exhibiting an excellent enhancement factor of 2.23 x 10(6) and a low limit-of-detection (LOD) of 3.84 nM for GABA molecules in water. Moreover, the ZnO/Cu@Ag substrate could recognize 10 nM GABA molecules in human serum. This GABA SERS sensor provides a reliable tool and technological support for research and applications in neuroscience and medicine.
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关键词
gamma-aminobutyric acid,Surface-enhanced Raman scattering (SERS),ZnO film,Metal-semiconductor heterojunction,ZnO/Cu@Ag substrate
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