口服中成药对原发性高血压患者动脉僵硬度影响的Meta分析

Objective To systematically evaluate the efficacy and safety of oral Chinese patent medicine on arterial stiffness in patients with essential hypertension(EH).Methods Randomized controlled trials concerning the effect of oral Chinese patent medicine on arterial stiffness in patients with EH from PubMed,Web of Science,The Cochrane Library,CNKI,Wanfang,and VIP database from their inception to August 31st 2022 were included by computer retrieval.Literatures were screened according to inclusion and exclusion criteria.Review Manager 5.4 and Stata 15.0 were used to make a meta-analysis after information extracting and quality evaluating.Results A total of 18 studies were included,involving eleven kinds of oral Chinese patent medicine and 1861 patients.The results of the traditional Meta-analysis showed that compared with the group only containing conventional western medicine(CWM),the combination of CWM and Xinmaitong Capsules(心脉通胶囊,XMT),Songling Xuemaikang Capsules(松龄血脉康胶囊,SLXMK),Xuezhikang Capsules(血脂康胶囊,XZK),Compound Danshen Dripping Pills(复方丹参滴丸,FFDSDW),Compound Danshen Tablets(复方丹参片,FFDSP),Compound Apocynum Granules(复方罗布麻颗粒,FFLBM),Huzhangye Capsules(虎杖叶胶囊,HZY),Qiju Dihuang Pills(杞菊地黄丸,QJDH),Guanxin Shutong Capsules(冠心舒通胶囊,GXST),Shexiang Baoxin Pills(香保心丸,SXBX),Yindan Xinnao Tong Soft Capsules(银丹心脑通软胶囊,YDXNT)can effectively decrease pulse wave velocity.The results of the network Meta-analysis showed that the top three optimal medication regimens were CWM combined with QJDH,FFDSP,and SXBX.The results of the traditional Meta-analysis showed that compared with the group only containing CWM,the combination of CWM and XMT,XZK,QJDH can effectively decrease pulse pressure;Compared with the group only containing CWM,the combination of CWM and XMT,SLXMK,XZK,FFDSDW,FFDSP,FFLBM,QJDH,GXST,YDXNT can effectively decrease systolic blood pressure.The results of the network Meta-analysis showed that the top three optimal medication regimens were CWM combined with QJDH,FFDSDW,and SLXMK.The results of the traditional Meta-analysis showed that compared with the group only containing CWM,the combination of CWM and XMT,SLXMK,FFDSDW,FFDSP,FFLBM,GXST can effectively decrease diastolic blood pressure.The results of the network Meta-analysis showed that the top three optimal medication regimens were CWM combined with FFDSP,FFDSDW,and FFLBM.In terms of adverse reactions,the combination of oral Chinese patent medicine and CWM had fewer adverse reactions and higher safety.Conclusion The combination of oral Chinese patent medicine and conventional western medicine can effectively improve arterial stiffness in patients with essential hypertension.However,limited by the quantity and quality of included studies,and the lack of direct comparison of oral Chinese patent medicine,the conclusion still needs to be verified by high quality,large sample and multicenter randomized double-blind controlled trials.