TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia

Dong-sheng Zhai,Xin-shang Wang,Le Yang,Yong-li Jiang, Yu-chen Jin, Yu-xuan Yan,Da-ke Song,Kun Zhang, Zu-kang Han, Ming-ying Liu,Yu-mei Wu,Xue Ma,Jing-yu Qi,Fan Yang,Fei Tian,Xu-bo Li,Shui-bing Liu

Journal of Affective Disorders（2024）

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摘要

ZBD-2 inhibited the inflammation and burst of superoxide (ROS, mtROS) under LPS stimulaiton. ZBD-2 protects mitochondria from LPS-induced damages through inhibiting the influx of calcium, which was achieved by increasing the level of expression of TOM40 and reducing the interaction of TSPO and TOM40.Unlabelled Image

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关键词

Translocator protein 18 kDa,ZBD-2,Postpartum depression,TOM40,Microglia

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