Dose addition in mixtures of compounds with dissimilar endocrine modes of action in in vitro receptor activation assays and the zebrafish sexual development test

Toine FH. Bovee,Harm J. Heusinkveld, Sophie Dodd,Ad Peijnenburg,Deborah Rijkers,Marco Blokland,R Corinne Sprong,Amélie Crépet, Antsje Nolles,Edwin P. Zwart,Eric R. Gremmer, Leo TM van der Ven

Food and Chemical Toxicology（2024）

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摘要

•Dietary and hazard data support mixture risk assessments.•Specific transcriptional activation assays are limited in testing complex mixtures.•Flutamide and dienestrol acted additively in the FSDT with zebrafish.

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关键词

Receptor,Estrogenic,Androgenic,Feminisation,Mode of action,Additivity

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