Twisted-chiral mesoporous silica from coconut husk waste designed for high-performance drug uptake and sustained release
MICROPOROUS AND MESOPOROUS MATERIALS(2024)
摘要
With an annual production of 2.81 million tons, the coconut husk is an essential source of silica. Various advantages of silica as a drug carrier make it one of the most developed materials in drug delivery applications. To improve the drug delivery performance of a material, twisted chirality is also classified as a critical factor because the pharmacological activity depends on the interaction of the drug with the drug carrier material in the target area. In this study, the coconut husk-based mesoporous silica (MS) can be synthesized through a calcination and sol-gel method. With the help of anionic surfactant, MS is successfully modified to have a twisted-chiral structure (CMS). CMS is characterized by twisted rod-like morphology at a size of 1-2 mu m, with a helical arrangement (mixed with the beta-sheet and random coil conformations). CMS's surface area and pore volume are obtained at 288.3 m(2)/g and 0.614 cm(3)/g, with an average pore size of 7.63 nm. The maximum adsorption of tetracycline (506.5 mg/g) is reached at pH = 4, with the initial concentration of tetracycline at 400 mg/g, temperature of 323 K, and adsorption time of 600 min. The loading of tetracycline follows the pseudo-first-order model with a monolayer mechanism. The bulk migration of tetracycline from the solution into the surface of CMS is deemed the primary adsorption mechanism. The in-vitro release study of tetracycline at pH = 7.4 follows the slow-sustained release model with the cumulative release at 72.3 %, showing better release performance compared with the common MS.
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关键词
twisted-chiral structure,tetracycline,mesoporous material,Drug uptake/release,Biomass-based silica,sustainable material
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