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The First Evidence of Mismatch Repair Deficiency in Mesonephric-Like Adenocarcinoma of the Endometrium: Clinicopathological and Molecular Features of a Case Emphasising a Possible Endometrioid Carcinogenesis.

Histopathology(2024)

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HistopathologyEarly View Correspondence The first evidence of mismatch repair deficiency in mesonephric-like adenocarcinoma of the endometrium: clinicopathological and molecular features of a case emphasising a possible endometrioid carcinogenesis Giuseppe Angelico, Corresponding Author Giuseppe Angelico [email protected] orcid.org/0000-0003-4808-2052 Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorLucia Salvatorelli, Lucia Salvatorelli Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorGiordana Tinnirello, Giordana Tinnirello Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorAngela Santoro, Angela Santoro Gynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalySearch for more papers by this authorGian Franco Zannoni, Gian Franco Zannoni orcid.org/0000-0002-4473-7560 Gynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalySearch for more papers by this authorLidia Puzzo, Lidia Puzzo Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorGaetano Magro, Gaetano Magro Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this author Giuseppe Angelico, Corresponding Author Giuseppe Angelico [email protected] orcid.org/0000-0003-4808-2052 Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorLucia Salvatorelli, Lucia Salvatorelli Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorGiordana Tinnirello, Giordana Tinnirello Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorAngela Santoro, Angela Santoro Gynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalySearch for more papers by this authorGian Franco Zannoni, Gian Franco Zannoni orcid.org/0000-0002-4473-7560 Gynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalySearch for more papers by this authorLidia Puzzo, Lidia Puzzo Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this authorGaetano Magro, Gaetano Magro Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, Anatomic Pathology, University of Catania, Catania, ItalySearch for more papers by this author First published: 03 January 2024 https://doi.org/10.1111/his.15136Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Mirkovic J, Olkhov-Mitsel E, Amemiya Y et al. Mesonephric-like adenocarcinoma of the female genital tract: novel observations and detailed molecular characterisation of mixed tumours and mesonephric-like carcinosarcomas. Histopathology 2023; 82; 978–990. 10.1111/his.14892 PubMedWeb of Science®Google Scholar 2 WHO Classification of Tumours Editorial Board. Female genital tumours. In WHO classification of tumours. 5th ed. Lyon, France: International Agency for Research on Cancer, 2020. Google Scholar 3Kenny SL, McBride HA, Jamison J, McCluggage WG. Mesonephric adenocarcinomas of the uterine cervix and corpus: Hpv-negative neoplasms that are commonly pax8, ca125, and hmga2 positive and that may be immunoreactive with ttf1 and hepatocyte nuclear factor 1-beta. Am. J. Surg. Pathol. 2012; 36; 799–807. 10.1097/PAS.0b013e31824a72c6 PubMedWeb of Science®Google Scholar 4Na K, Kim HS. Clinicopathologic and molecular characteristics of mesonephric adenocarcinoma arising from the uterine body. Am. J. Surg. Pathol. 2019; 43; 12–25. 10.1097/PAS.0000000000000991 PubMedWeb of Science®Google Scholar 5Choi S, Na K, Kim SW, Kim HS. Dedifferentiated mesonephric like adenocarcinoma of the uterine corpus. Anticancer Res 2021; 41; 2719–2726. 10.21873/anticanres.15053 PubMedWeb of Science®Google Scholar 6Mirza MR, Chase DM, Slomovitz BM et al. Dostarlimab for primary advanced or recurrent endometrial cancer. N. Engl. J. Med. 2023; 388; 2145–2158. 10.1056/NEJMoa2216334 CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation
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