O -Alkyl-3,5-di- tert -butyl-4-hydroxybenzylchlorophosphonates in the Synthesis of New Phosphonamidates Containing Sterically Hindered Phenolic and N-Heterocyclic Fragments

A. M. Shakirov,E. M. Gibadullina, E. A. Chugunova,A. R. Burilov

Russian Journal of General Chemistry（2023）

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摘要

A series of eight new phosphonamidates containing sterically hindered phenolic and N-heterocyclic fragments was obtained and characterized. The synthesis is based on the reaction of O -alkyl-3,5-di- tert -butyl-4-hydroxybenzylchlorophosphonates with aliphatic amines.

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phosphonamidate,sterically hindered phenol,N-heterocycles,drug design,antitumor agents

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