Association of Primary Open-Angle Glaucoma with Diabetic Retinopathy Among Patients with Type 1 and Type 2 Diabetes: A Large Global Database Study

Ophthalmology(2024)

引用 0|浏览1
暂无评分
摘要
PURPOSE:To assess the correlation between primary open-angle glaucoma (POAG) and the risk of developing diabetic retinopathy (DR) in patients with type 1 and type 2 diabetes mellitus (DM). DESIGN:A retrospective cohort study leveraging the global patient database of TriNetX Research Network. SUBJECTS:The study included 44,359 DM patients with POAG and 4,393,300 DM patients without any glaucoma ≥18 years of age. Propensity score matching harmonized the cohorts to 39,680 patients each covering diagnoses from January 1, 2005, to January 1, 2023. METHODS:We analyzed data using specific ICD-10 codes for DM and glaucoma. We matched the cohorts using propensity score matching, adjusting for age, sex, race/ethnicity, blood markers, relevant medical history, and ophthalmic service utilization. MAIN OUTCOME MEASURES:The primary outcome was the first-time occurrence of DR, including non-proliferative DR (NPDR), and proliferative DR (PDR), in DM patients with and without glaucoma at 1, 5, and 10-year intervals from their individual index dates. RESULTS:At 10 years, T1DM patients with POAG exhibited a heightened risk for any DR (adjusted risk ratios (RR): 4.12; 95% CI: 3.05-5.57, p<0.0001) and PDR (RR: 7.02; 95% CI: 3.62- 13.61, p<0.0001). T2DM patients with POAG also faced an increased 10-year risk for any DR (RR: 2.47; 95% CI: 2.28- 2.68, p<0.0001) and PDR (RR: 3.82; 95% CI: 3.09- 4.70, p<0.0001). The combined association of POAG on DR risk in T1DM and T2DM at 10 years was found to be significantly higher among POAG patients (5.45%) compared to those without glaucoma (2.12%) (adjusted hazard ratios (aHR): 2.33; 95% CI: 2.14-2.53). The cumulative incidence of DR was significantly higher in the POAG group compared to non-glaucoma counterparts after a decade (log-rank p < 0.001). CONCLUSIONS:Our findings underscore a substantial association between POAG and DR development in both T1DM and T2DM patients, emphasizing the need for vigilant screening and comprehensive management in glaucomatous patients with DM to mitigate the risk of DR. Future research should delve into elucidating the causal mechanisms driving these observed associations.
更多
查看译文
关键词
Glaucoma,diabetic retinopathy,retrospective cohort study,TriNetX Research Network,propensity score matching,T1DM,T2DM
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要