Regioselective C3Alkylation of Indoles for the Synthesis of Bis(indolyl)methanes and 3-Styryl Indoles

JOURNAL OF ORGANIC CHEMISTRY(2024)

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摘要
Herein, we describe an efficient transition-metal-free regioselective C(3)alkylation of indoles for the synthesis of bis-(indolyl)-methanes and 3-styryl indoles. Nitrobenzene is employed as the oxidant to oxidize the alcohols in the presence of a strong base and the reaction avoids the use of transition metals such as Ru and Mn. The protocol provides a favorable route to access biologically active compounds such as arundine, vibrindole A, and turbomycin B.
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