Polygenic risk for depression predicting temperament trajectories over 15 years – A general population study

Veikka Lavonius,Liisa Keltikangas-Järvinen,Binisha Hamal Mishra,Elina Sormunen,Mika Kähönen,Olli Raitakari,Jarmo Hietala,C. Robert Cloninger,Terho Lehtimäki,Aino Saarinen

Journal of affective disorders（2024）

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摘要

•We examined if polygenic risk for major depression (PRS) predicts temperament traits.•High PRS predicted higher Persistence from early adulthood to middle age.•PRS was not related to Novelty seeking or Reward dependence.•The link of Anticipatory Worry with depressive symptoms was stronger if having high PRS.•The results remained when excluding participants with diagnosed affective disorders.

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关键词

Polygenic risk score,Depressive symptoms,TCI,Temperament,Persistence,Longitudinal study

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Polygenic risk for depression predicting temperament trajectories over 15 years – A general population study

Polygenic risk for depression predicting temperament trajectories over 15 years – A general population study